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Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling.


ABSTRACT: A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1-4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.

SUBMITTER: Senecal TD 

PROVIDER: S-EPMC3093444 | BioStudies | 2011-01-01

REPOSITORIES: biostudies

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