Dataset Information


B7-h2 is a costimulatory ligand for CD28 in human.

ABSTRACT: CD28 and CTLA-4 are cell surface cosignaling molecules essential for the control of T cell activation upon the engagement of their ligands B7-1 and B7-2 from antigen-presenting cells. By employing a receptor array assay, we have demonstrated that B7-H2, best known as the ligand of inducible costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 and B7-1 or B7-2 interacted with CD28 through distinctive domains. B7-H2-CD28 interaction was essential for the costimulation of human T cells' primary responses to allogeneic antigens and memory recall responses. Similar to B7-1 and B7-2, B7-H2 costimulation via CD28 induced survival factor Bcl-xL, downregulated cell cycle inhibitor p27(kip1), and triggered signaling cascade of ERK and AKT kinase-dependent pathways. Our findings warrant re-evaluation of CD28 and CTLA-4's functions previously attributed exclusively to B7-1 and B7-2 and have important implications in therapeutic interventions against human diseases.


PROVIDER: S-EPMC3103603 | BioStudies | 2011-01-01

REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6399415 | BioStudies
| S-EPMC2707944 | BioStudies
2016-01-01 | S-EPMC5081635 | BioStudies
2019-01-01 | S-EPMC6503043 | BioStudies
1000-01-01 | S-EPMC2191786 | BioStudies
1000-01-01 | S-EPMC4161918 | BioStudies
2017-01-01 | S-EPMC5341606 | BioStudies
1000-01-01 | S-EPMC3064430 | BioStudies
2001-01-01 | S-EPMC2193370 | BioStudies
2020-01-01 | S-EPMC7096747 | BioStudies