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X-ray diffraction experiment--the last experiment in the structure elucidation process.


ABSTRACT: Recent years have brought not only an avalanche of new macromolecular structures, but also significant advances in the protein structure determination methodology only now making its way into structure-based drug discovery. In this chapter, we review recent methodology developments in X-ray diffraction experiments that led to fast and very accurate elucidation of three-dimensional structures of macromolecules. We will discuss the role of data collection as the last experiment performed in the crystal structure determination process. A statistical analysis of diffraction experiments that are reported in the Protein Data Bank (PDB) is also presented.

SUBMITTER: Chruszcz M 

PROVIDER: S-EPMC3128764 | BioStudies | 2009-01-01T00:00:00Z

SECONDARY ACCESSION(S): 130K

REPOSITORIES: biostudies

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