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Nanoscale studies of protein-membrane interactions in blood clotting.


ABSTRACT: Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

SUBMITTER: Morrissey JH 

PROVIDER: S-EPMC3151027 | BioStudies | 2011-01-01

REPOSITORIES: biostudies

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