Dataset Information


Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection.

ABSTRACT: Objectives. We investigated immune phenotypes of HIV+ patients who present late, considering late presenters (LPs, CD4+ < 350/?L and/or AIDS), advanced HIV disease (AHD, CD4+ < 200/?L and/or AIDS), and AIDS presenters (AIDS-defining condition at presentation, independently from CD4+). Methods. Patients newly diagnosed with HIV at our clinic between 2007-2011 were enrolled. Mann-Whitney/Chi-squared tests and logistic regression were used for statistics. Results. 275 patients were newly diagnosed with HIV between January/2007-March/2011. 130 (47%) were LPs, 79 (29%) showed AHD, and 49 (18%) were AIDS presenters. LP, AHD, and AIDS presenters were older and more frequently heterosexuals. Higher CD8+%, lower CD127+CD4+%, higher CD95+CD8+%, CD38+CD8+%, and CD45R0+CD38+CD8+% characterized LP/AHD/AIDS presentation. In multivariate analysis, older age, heterosexuality, higher CD8+%, and lower CD127+CD4+% were confirmed associated with LP/AHD. Lower CD4+ and higher CD38+CD8+% resulted independently associated with AIDS presentation. Conclusions. CD127 downregulation and immune activation characterize HIV+ patients presenting late and would be studied as additional markers of late presentation.


PROVIDER: S-EPMC3205670 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC5988738 | BioStudies
2019-01-01 | S-EPMC6927630 | BioStudies
1000-01-01 | S-EPMC4907649 | BioStudies
1000-01-01 | S-EPMC4779961 | BioStudies
1000-01-01 | S-EPMC4585954 | BioStudies
2018-01-01 | S-EPMC6307234 | BioStudies
2019-01-01 | S-EPMC7397713 | BioStudies
2011-01-01 | S-EPMC3031543 | BioStudies
2014-01-01 | S-EPMC4090061 | BioStudies
2010-01-01 | S-EPMC2825253 | BioStudies