Unknown

Dataset Information

0

Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease.


ABSTRACT: Clinical studies using bone marrow-derived proangiogenic cells (PACs) have demonstrated modest improvements of function and/or perfusion of ischemic myocardium or skeletal muscle. Because the identities of these PACs and their functional ability to promote neovascularization remain poorly understood, it is possible that a subset of robust PACs exists but is obscured by the heterogeneous nature of this cell population. Herein, we found that common myeloid progenitors (CMPs) and granulocyte-macrophage progenitors (GMPs) preferentially differentiate into PACs compared with megakaryocyte-erythrocyte progenitors, hematopoietic stem cells, and common lymphoid progenitors. In vivo hindlimb ischemia studies and Matrigel plug assays verified the enhanced neovascularization properties uniquely associated with PACs derived from CMPs and GMPs. Taken together, these observations identify CMPs and GMPs as key bone marrow progenitors for optimal PAC function in vitro and in vivo and provide a foundation for novel therapeutic approaches to modulate angiogenesis.

SUBMITTER: Wara AK 

PROVIDER: S-EPMC3236127 | BioStudies | 2011-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC3236126 | BioStudies
2019-01-01 | S-EPMC6813769 | BioStudies
1000-01-01 | S-EPMC4793235 | BioStudies
1000-01-01 | S-EPMC1895406 | BioStudies
1000-01-01 | S-EPMC2676094 | BioStudies
2014-01-01 | S-EPMC4062101 | BioStudies
2020-01-01 | S-EPMC7472865 | BioStudies
2017-01-01 | S-EPMC5726802 | BioStudies
2011-01-01 | S-EPMC3168991 | BioStudies
1000-01-01 | S-EPMC5867061 | BioStudies