Dataset Information


An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic Fever arenaviruses.

ABSTRACT: Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that all NW hemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers.

SUBMITTER: Helguera G 

PROVIDER: S-EPMC3302512 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

Similar Datasets

2014-01-01 | S-EPMC4136298 | BioStudies
2009-01-01 | S-EPMC2725543 | BioStudies
2009-01-01 | S-EPMC2658809 | BioStudies
1000-01-01 | S-EPMC2441566 | BioStudies
2015-01-01 | S-EPMC4325705 | BioStudies
2018-01-01 | S-EPMC5974477 | BioStudies
2014-01-01 | S-EPMC4054455 | BioStudies
2009-01-01 | S-EPMC2795640 | BioStudies
2012-01-01 | S-EPMC3426302 | BioStudies
2011-01-01 | S-EPMC3057843 | BioStudies