Dataset Information


Structure of AKR1C3 with 3-phenoxybenzoic acid bound.

ABSTRACT: Aldo-keto reductase 1C3 (AKR1C3) is a human enzyme that catalyzes the NADPH-dependent reduction of steroids and prostaglandins. AKR1C3 overexpression is associated with the proliferation of hormone-dependent cancers, most notably breast and prostate cancers. Nonsteroidal anti-inflammatory drugs (NSAIDs) and their analogues are well characterized inhibitors of AKR1C3. Here, the X-ray crystal structure of 3-phenoxybenzoic acid in complex with AKR1C3 is presented. This structure provides useful information for the future development of new anticancer agents by structure-guided drug design.

PROVIDER: S-EPMC3325808 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC3047600 | BioStudies
| S-EPMC5931143 | BioStudies
| S-EPMC7766127 | BioStudies
| S-EPMC3805777 | BioStudies
| S-EPMC4038446 | BioStudies
| S-EPMC4983729 | BioStudies
| S-EPMC6422768 | BioStudies
| S-EPMC3057412 | BioStudies
| S-EPMC4125433 | BioStudies
| S-EPMC7693014 | BioStudies