Unknown

Dataset Information

0

Peripheral nervous system function and organophosphate pesticide use among licensed pesticide applicators in the Agricultural Health Study.


ABSTRACT:

Background

Evidence is limited that long-term human exposure to organophosphate (OP) pesticides, without poisoning, is associated with adverse peripheral nervous system (PNS) function.

Objective

We investigated associations between OP pesticide use and PNS function by administering PNS tests to 701 male pesticide applicators in the Agricultural Health Study (AHS).

Methods

Participants completed a neurological physical examination (NPx) and electrophysiological tests as well as tests of hand strength, sway speed, and vibrotactile threshold. Self-reported information on lifetime use of 16 OP pesticides was obtained from AHS interviews and a study questionnaire. Associations between pesticide use and measures of PNS function were estimated with linear and logistic regression controlling for age and outcome-specific covariates.

Results

Significantly increased odds ratios (ORs) were observed for associations between ever use of 10 of the 16 OP pesticides and one or more of six NPx outcomes. Most notably, abnormal toe proprioception was significantly associated with ever use of 6 OP pesticides, with ORs ranging from 2.03 to 3.06; monotonic increases in strength of association with increasing use was observed for 3 of the 6 pesticides. Mostly null associations were observed between OP pesticide use and electrophysiological tests, hand strength, sway speed, and vibrotactile threshold.

Conclusions

This study provides some evidence that long-term exposure to OP pesticides is associated with signs of impaired PNS function among pesticide applicators.

SUBMITTER: Starks SE 

PROVIDER: S-EPMC3339452 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5744702 | BioStudies
2010-01-01 | S-EPMC2935660 | BioStudies
2013-01-01 | S-EPMC3734498 | BioStudies
2015-01-01 | S-EPMC4510132 | BioStudies
2018-01-01 | S-EPMC6375417 | BioStudies
2012-01-01 | S-EPMC3478402 | BioStudies
1000-01-01 | S-EPMC5381995 | BioStudies
2019-01-01 | S-EPMC6470005 | BioStudies
2014-01-01 | S-EPMC3936597 | BioStudies
2011-01-01 | S-EPMC3261977 | BioStudies