Dataset Information


Structure of Salmonella effector protein SopB N-terminal domain in complex with host Rho GTPase Cdc42.

ABSTRACT: SopB is a type III secreted Salmonella effector protein with phosphoinositide phosphatase activity and a distinct GTPase binding domain. The latter interacts with host Cdc42, an essential Rho GTPase that regulates critical events in eukaryotic cytoskeleton organization and membrane trafficking. Structural and biochemical analysis of the SopB GTPase binding domain in complex with Cdc42 shows for the first time that SopB structurally and functionally mimics a host guanine nucleotide dissociation inhibitor (GDI) by contacting key residues in the regulatory switch regions of Cdc42 and slowing Cdc42 nucleotide exchange.

SUBMITTER: Burkinshaw BJ 

PROVIDER: S-EPMC3339929 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC5030135 | BioStudies
2016-01-01 | S-EPMC5956535 | BioStudies
2013-01-01 | S-EPMC3861033 | BioStudies
2009-01-01 | S-EPMC2805562 | BioStudies
1000-01-01 | S-EPMC2441673 | BioStudies
2015-01-01 | S-EPMC4383620 | BioStudies
2013-01-01 | S-EPMC3542069 | BioStudies
2008-01-01 | S-EPMC2364637 | BioStudies
2010-01-01 | S-EPMC2842064 | BioStudies
2017-01-01 | S-EPMC5471308 | BioStudies