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Homeostatic regulation of Salmonella-induced mucosal inflammation and injury by IL-23.


ABSTRACT: IL-12 and IL-23 regulate innate and adaptive immunity to microbial pathogens through influencing the expression of IFN-?, IL-17, and IL-22. Herein we define the roles of IL-12 and IL-23 in regulating host resistance and intestinal inflammation during acute Salmonella infection. We find that IL-23 alone is dispensable for protection against systemic spread of bacteria, but synergizes with IL-12 for optimal protection. IL-12 promotes the production of IFN-? by NK cells, which is required for resistance against Salmonella and also for induction of intestinal inflammation and epithelial injury. In contrast, IL-23 controls the severity of inflammation by inhibiting IL-12A expression, reducing IFN-? and preventing excessive mucosal injury. Our studies demonstrate that IL-23 is a homeostatic regulator of IL-12-dependent, IFN-?-mediated intestinal inflammation.

SUBMITTER: Awoniyi M 

PROVIDER: S-EPMC3356277 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

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