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Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.


ABSTRACT: Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease.

PROVIDER: S-EPMC3368817 | BioStudies | 2012-01-01T00:00:00Z

REPOSITORIES: biostudies

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