Dataset Information


Mining the pharmacogenomics literature--a survey of the state of the art.

ABSTRACT: This article surveys efforts on text mining of the pharmacogenomics literature, mainly from the period 2008 to 2011. Pharmacogenomics (or pharmacogenetics) is the field that studies how human genetic variation impacts drug response. Therefore, publications span the intersection of research in genotypes, phenotypes and pharmacology, a topic that has increasingly become a focus of active research in recent years. This survey covers efforts dealing with the automatic recognition of relevant named entities (e.g. genes, gene variants and proteins, diseases and other pathological phenomena, drugs and other chemicals relevant for medical treatment), as well as various forms of relations between them. A wide range of text genres is considered, such as scientific publications (abstracts, as well as full texts), patent texts and clinical narratives. We also discuss infrastructure and resources needed for advanced text analytics, e.g. document corpora annotated with corresponding semantic metadata (gold standards and training data), biomedical terminologies and ontologies providing domain-specific background knowledge at different levels of formality and specificity, software architectures for building complex and scalable text analytics pipelines and Web services grounded to them, as well as comprehensive ways to disseminate and interact with the typically huge amounts of semiformal knowledge structures extracted by text mining tools. Finally, we consider some of the novel applications that have already been developed in the field of pharmacogenomic text mining and point out perspectives for future research.


PROVIDER: S-EPMC3404399 | BioStudies | 2012-01-01T00:00:00Z


REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7748107 | BioStudies
2010-01-01 | S-EPMC3035632 | BioStudies
2016-01-01 | S-EPMC4907256 | BioStudies
2018-01-01 | S-EPMC5773052 | BioStudies
2014-01-01 | S-EPMC4177665 | BioStudies
2019-01-01 | S-EPMC6804983 | BioStudies
2017-01-01 | S-EPMC5664974 | BioStudies
2020-01-01 | S-EPMC7206783 | BioStudies
2015-01-01 | S-EPMC4441820 | BioStudies
2017-01-01 | S-EPMC5509952 | BioStudies