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Identification of a residue affecting fatty alcohol selectivity in wax ester synthase.


ABSTRACT: The terminal enzyme in the bacterial wax ester biosynthetic pathway is the bifunctional wax ester synthase/acyl-coenzyme A:diacylglycerol acyltransferase (WS/DGAT), which utilizes a fatty alcohol and a fatty acyl-coenzyme A (CoA) to synthesize the corresponding wax ester. In this report, we identify a specific residue in WS/DGAT enzymes obtained from Marinobacter aquaeolei VT8 and Acinetobacter baylyi that alters fatty alcohol selectivity and kinetic parameters when modified to alternative residues.

SUBMITTER: Barney BM 

PROVIDER: S-EPMC3536089 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

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