Unknown

Dataset Information

0

Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.


ABSTRACT: It is widely believed that the molecular and cellular features of a tumor reflect its cell of origin and can thus provide clues about treatment targets. The retinoblastoma cell of origin has been debated for over a century. Here, we report that human and mouse retinoblastomas have molecular, cellular, and neurochemical features of multiple cell classes, principally amacrine/horizontal interneurons, retinal progenitor cells, and photoreceptors. Importantly, single-cell gene expression array analysis showed that these multiple cell type-specific developmental programs are coexpressed in individual retinoblastoma cells, which creates a progenitor/neuronal hybrid cell. Furthermore, neurotransmitter receptors, transporters, and biosynthetic enzymes are expressed in human retinoblastoma, and targeted disruption of these pathways reduces retinoblastoma growth in vivo and in vitro.

SUBMITTER: McEvoy J 

PROVIDER: S-EPMC3551581 | BioStudies | 2011-01-01

REPOSITORIES: biostudies

Similar Datasets

2011-06-07 | GSE29685 | GEO
2011-06-07 | E-GEOD-29684 | ArrayExpress
| GSE29684 | GEO
2011-06-07 | E-GEOD-29683 | ArrayExpress
| PRJNA141209 | ENA
2013-01-01 | S-EPMC3721394 | BioStudies
2011-06-07 | E-GEOD-29686 | ArrayExpress
2018-01-01 | S-EPMC6176579 | BioStudies
2009-01-01 | S-EPMC5659855 | BioStudies
2017-01-01 | S-EPMC5508517 | BioStudies