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Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence.


ABSTRACT: We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.

SUBMITTER: Reid SD 

PROVIDER: S-EPMC355993 | BioStudies | 2004-01-01

SECONDARY ACCESSION(S): 10.1128/IAI.72.3.1799-1803.2004

REPOSITORIES: biostudies

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