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Confirming glycemic status in the Diabetes Prevention Program: implications for diagnosing diabetes in high risk adults.


ABSTRACT:

Aims

To examine the ability of fasting plasma glucose (FPG) and/or 2-h glucose to confirm diabetes and to determine the proportion of participants with HbA1c ?6.5%.

Methods

Diabetes confirmation rates were calculated after a single elevated FPG and/or 2-h glucose on an oral glucose tolerance test (OGTT) using a confirmatory OGTT performed within 6 weeks.

Results

772 (24%) participants had elevated FPG or 2-h glucose on an OGTT that triggered a confirmation visit. There were 101 triggers on FPG alone, 574 on 2-h glucose alone, and 97 on both. Only 47% of participants who triggered had confirmed diabetes. While the confirmation rate for FPG was higher than that for 2-h glucose, the larger number of 2-h glucose triggers resulted in 87% of confirmed cases triggering on 2-h glucose. Confirmation rates increased to 75% among persons with FPG ?126 mg/dl and HbA1c ?6.5%.

Conclusions

Only half of the persons with elevated FPG and IGT were subsequently confirmed to have diabetes. At current diagnostic levels, more persons trigger on 2-h glucose than on FPG, but fewer of these persons have their diagnoses confirmed. In individuals with FPG ?126 mg/dl and HbA1c ?6.5%, the confirmation rate was increased.

SUBMITTER: Christophi CA 

PROVIDER: S-EPMC3594066 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

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