Dataset Information


Fecal microbiota composition differs between children with β-cell autoimmunity and those without.

ABSTRACT: The role of the intestinal microbiota as a regulator of autoimmune diabetes in animal models is well-established, but data on human type 1 diabetes are tentative and based on studies including only a few study subjects. To exclude secondary effects of diabetes and HLA risk genotype on gut microbiota, we compared the intestinal microbiota composition in children with at least two diabetes-associated autoantibodies (n = 18) with autoantibody-negative children matched for age, sex, early feeding history, and HLA risk genotype using pyrosequencing. Principal component analysis indicated that a low abundance of lactate-producing and butyrate-producing species was associated with β-cell autoimmunity. In addition, a dearth of the two most dominant Bifidobacterium species, Bifidobacterium adolescentis and Bifidobacterium pseudocatenulatum, and an increased abundance of the Bacteroides genus were observed in the children with β-cell autoimmunity. We did not find increased fecal calprotectin or IgA as marker of inflammation in children with β-cell autoimmunity. Functional studies related to the observed alterations in the gut microbiome are warranted because the low abundance of bifidobacteria and butyrate-producing species could adversely affect the intestinal epithelial barrier function and inflammation, whereas the apparent importance of the Bacteroides genus in development of type 1 diabetes is insufficiently understood.

SUBMITTER: de Goffau MC 

PROVIDER: S-EPMC3609581 | BioStudies | 2013-01-01


REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6842923 | BioStudies
2017-01-01 | S-EPMC5603605 | BioStudies
1000-01-01 | S-EPMC4757479 | BioStudies
2016-01-01 | S-EPMC4974821 | BioStudies
2019-01-01 | S-EPMC6857132 | BioStudies
2020-01-01 | S-EPMC7096501 | BioStudies
2014-01-01 | S-EPMC3929570 | BioStudies
1000-01-01 | S-EPMC6065514 | BioStudies
2010-01-01 | S-EPMC2964251 | BioStudies
2018-01-01 | S-EPMC5862971 | BioStudies