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White paper: landscape on technical and conceptual requirements and competence framework in drug/disease modeling and simulation.


ABSTRACT: Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher-level understanding of drugs, (diseased)systems, and their interactions (systems pharmacology) through mathematical/statistical models (pharmacometrics)(1)-hence facilitating decision making during drug development and therapeutic usage of medicines. To identify gaps and challenges in DDM&S, an inventory of skills and competencies currently available in academia, industry, and clinical practice was obtained through survey. The survey outcomes revealed benefits, weaknesses, and hurdles for the implementation of DDM&S. In addition, the survey indicated that no consensus exists about the knowledge, skills, and attributes required to perform DDM&S activities effectively. Hence, a landscape of technical and conceptual requirements for DDM&S was identified and serves as a basis for developing a framework of competencies to guide future education and training in DDM&S.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e40; doi:10.1038/psp.2013.16; advance online publication 1 May 2013.

SUBMITTER: Vlasakakis G 

PROVIDER: S-EPMC3674326 | BioStudies | 2013-01-01T00:00:00Z

REPOSITORIES: biostudies

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White paper: landscape on technical and conceptual requirements and competence framework in drug/disease modeling and simulation.

Vlasakakis G G   Comets E E   Keunecke A A   Gueorguieva I I   Magni P P   Terranova N N   Della Pasqua O O   de Lange E C EC   Kloft C C  

CPT: pharmacometrics & systems pharmacology 20130501


Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher-level understanding of drugs, (diseased)systems, and their interactions (systems pharmacology) through mathematical/statistical models (pharmacometrics)(1)-hence facilitating decision ma  ...[more]

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