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Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism.


ABSTRACT: Polyglutamine (PolyQ) aggregates are a hallmark of several severe neurodegenerative diseases, expanded CAG-repeat diseases in which inheritance of an expanded polyQ sequence above a pathological threshold is associated with a high risk of disease. Application of vibrational circular dichroism (VCD) reveals that these PolyQ fibril aggregates exhibit a chiral supramolecular organization that is distinct from the supramolecular organization of previously observed amyloid fibrils. PolyQ fibrils grown from monomers with Q repeats 35 and above (Q?35) exhibit approximately 10-fold enhancement of the same VCD spectrum compared to the already enhanced VCD of fibrils formed from Q repeats 30 and below (Q?30).

SUBMITTER: Kurouski D 

PROVIDER: S-EPMC3685276 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

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