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Calbindin controls release probability in ventral tegmental area dopamine neurons.


ABSTRACT: Relatively little is known about the molecular control of midbrain dopamine release. Using high-fidelity imaging of pHluorin-tagged vesicular monoamine transporter 2 in dopamine neurons, we found that exocytosis was more loosely coupled to calcium entry than in fast synapses. In ventral tegmental area neurons, this allows exocytosis to be efficiently controlled by a native fast calcium buffer, calbindin-D28k, maintaining a lower vesicular release probability compared with substantia nigra neurons.

SUBMITTER: Pan PY 

PROVIDER: S-EPMC3703651 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

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