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Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.


ABSTRACT: ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.

PROVIDER: S-EPMC3726583 | BioStudies |

REPOSITORIES: biostudies

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2017-12-14 | PXD008083 | Pride