Dataset Information


Force produced after stretch in sarcomeres and half-sarcomeres isolated from skeletal muscles.

ABSTRACT: The goal of this study was to evaluate if isolated sarcomeres and half-sarcomeres produce a long-lasting increase in force after a stretch is imposed during activation. Single and half-sarcomeres were isolated from myofibrils using micro-needles, which were also used for force measurements. After full force development, both preparations were stretched by different magnitudes. The sarcomere length (SL) or half-sarcomere length variations (HSL) were extracted by measuring the initial and final distances from the Z-line to the adjacent Z-line or to a region externally adjacent to the M-line of the sarcomere, respectively. Half-sarcomeres generated approximately the same amount of isometric force (29.0 ± SD 15.5?nN·?m(-2)) as single sarcomeres (32.1 ± SD 15.3?nN·?m(-2)) when activated. In both cases, the steady-state forces after stretch were higher than the forces during isometric contractions at similar conditions. The results suggest that stretch-induced force enhancement is partly caused by proteins within the half-sarcomere.

PROVIDER: S-EPMC3728588 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC3182863 | BioStudies
| S-EPMC2770126 | BioStudies
| S-EPMC7176582 | BioStudies
2015-01-01 | S-EPMC4453107 | BioStudies
| S-EPMC4821266 | BioStudies
| S-EPMC2694683 | BioStudies
| S-EPMC6171862 | BioStudies
| S-EPMC5725405 | BioStudies
| S-EPMC125597 | BioStudies
| S-EPMC7235410 | BioStudies