Dataset Information


Site-specific identification of an a? fibril-heparin interaction site by using solid-state NMR spectroscopy.

ABSTRACT: At the surface of A?(1-40) amyloid fibrils that have a threefold molecular symmetry (green in the left picture) a site of interaction of the glycosaminoglycan analogue heparin (blue) was identified. The binding site consists of residues at the N terminus and the turn regions defining the apices of the triangular geometry. Heparin has a lower affinity for A?(1-40) fibrils having twofold molecular symmetry, thus revealing a remarkable morphological selectivity.

PROVIDER: S-EPMC3749465 | BioStudies |

REPOSITORIES: biostudies

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