Unknown

Dataset Information

0

Site-specific identification of an a? fibril-heparin interaction site by using solid-state NMR spectroscopy.


ABSTRACT: At the surface of A?(1-40) amyloid fibrils that have a threefold molecular symmetry (green in the left picture) a site of interaction of the glycosaminoglycan analogue heparin (blue) was identified. The binding site consists of residues at the N terminus and the turn regions defining the apices of the triangular geometry. Heparin has a lower affinity for A?(1-40) fibrils having twofold molecular symmetry, thus revealing a remarkable morphological selectivity.

PROVIDER: S-EPMC3749465 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC9307803 | BioStudies
| S-EPMC3045480 | BioStudies
| S-EPMC3123057 | BioStudies
| S-EPMC8363829 | BioStudies
| S-EPMC3068913 | BioStudies
| S-EPMC5910196 | BioStudies
| S-EPMC5548265 | BioStudies
| S-EPMC7464290 | BioStudies
| S-EPMC3235348 | BioStudies
| S-EPMC4913942 | BioStudies