Dataset Information


Gene network analysis in a pediatric cohort identifies novel lung function genes.

ABSTRACT: Lung function is a heritable trait and serves as an important clinical predictor of morbidity and mortality for pulmonary conditions in adults, however, despite its importance, no studies have focused on uncovering pediatric-specific loci influencing lung function. To identify novel genetic determinants of pediatric lung function, we conducted a genome-wide association study (GWAS) of four pulmonary function traits, including FVC, FEV1, FEV1/FVC and FEF25-75% in 1556 children. Further, we carried out gene network analyses for each trait including all SNPs with a P-value of <1.0 × 10(-3) from the individual GWAS. The GWAS identified SNPs with notable trends towards association with the pulmonary function measures, including the previously described INTS12 locus association with FEV1 (pmeta=1.41 × 10(-7)). The gene network analyses identified 34 networks of genes associated with pulmonary function variables in Caucasians. Of those, the glycoprotein gene network reached genome-wide significance for all four variables. P-value range pmeta=6.29 × 10(-4) - 2.80 × 10(-8) on meta-analysis. In this study, we report on specific pathways that are significantly associated with pediatric lung function at genome-wide significance. In addition, we report the first loci associated with lung function in both pediatric Caucasian and African American populations.


PROVIDER: S-EPMC3759429 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3776747 | BioStudies
2014-01-01 | S-EPMC4136502 | BioStudies
2015-01-01 | S-EPMC4668640 | BioStudies
2018-01-01 | S-EPMC6090900 | BioStudies
2014-01-01 | S-EPMC4270121 | BioStudies
2016-01-01 | S-EPMC4709100 | BioStudies
2018-01-01 | S-EPMC6058984 | BioStudies
2020-01-01 | S-EPMC6946810 | BioStudies
2010-01-01 | S-EPMC2832852 | BioStudies
2008-05-31 | GSE8581 | GEO