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PARP-1 regulates expression of TGF-? receptors in T cells.

ABSTRACT: Transforming growth factor-? (TGF-?) receptors (T?Rs) are essential components for TGF-? signal transduction in T cells, yet the mechanisms by which the receptors are regulated remain poorly understood. We show here that Poly(ADP-ribose) polymerase-1 (PARP-1) regulates TGF-? receptor I (T?RI) and II (T?RII) expression in CD4(+) T cells and subsequently affects Smad2/3-mediated TGF-? signal transduction. Inhibition of PARP-1 led to the upregulation of both T?RI and T?RII, yet the underlying molecular mechanisms were distinct. PARP-1 selectively bound to the promoter of T?RII, whereas the enzymatic activity of PARP-1 was responsible for the inhibition of T?RI expression. Importantly, inhibition of PARP-1 also enhanced expression of T?Rs in human CD4(+) T cells. Thus, PARP-1 regulates T?R expression and TGF-? signaling in T cells.

PROVIDER: S-EPMC3785120 | BioStudies |

REPOSITORIES: biostudies

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