Unknown

Dataset Information

0

LHRH and LHR genotypes and prostate cancer incidence and survival.


ABSTRACT: Despite their crucial role in initiating steroid-hormone synthesis, the hypothalamic and pituitary hormones (LH, LHRH) and their receptors have received scant attention in genetic studies of hormone-related diseases. This study included 1,170 men diagnosed with prostate cancer (PC) in Los Angeles County between 1999 and 2003. LHRH and LH receptor genotypes were examined for association with PC survival. Additionally, associations with PC incidence were examined by comparing PC cases to control men of similar age and race/ethnicity. The LHR 312 G allele was found to be associated with increased PC mortality (p=0.01). Ten years after diagnosis, 16% of men carrying two copies of the G allele (genotype GG) had died of PC, compared to 11% of those with genotype AG and 9% of those with AA. In a case-control comparison, this same allele was significantly associated with decreased PC risk: OR=0.68 (95% CI: 0.49, 0.93) for genotype GG vs. AA. These results suggest that androgens may play opposing roles in PC initiation and progression, and highlight the need to include these important but overlooked genes in future studies of PC etiology, prognosis, and treatment.

SUBMITTER: Ingles SA 

PROVIDER: S-EPMC3852642 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

Similar Datasets

2001-01-01 | S-EPMC59791 | BioStudies
1985-01-01 | S-EPMC1152838 | BioStudies
2011-01-01 | S-EPMC2997383 | BioStudies
1986-01-01 | S-EPMC1146784 | BioStudies
2009-01-01 | S-EPMC2654512 | BioStudies
2017-01-01 | S-EPMC5633567 | BioStudies
2017-01-01 | S-EPMC6171772 | BioStudies
2015-01-01 | S-EPMC4681734 | BioStudies
2013-01-01 | S-EPMC3734527 | BioStudies
2015-01-01 | S-EPMC4361359 | BioStudies