Dataset Information


Respiratory-gated MRgHIFU in upper abdomen using an MR-compatible in-bore digital camera.

ABSTRACT: OBJECTIVE: To demonstrate the technical feasibility and the potential interest of using a digital optical camera inside the MR magnet bore for monitoring the breathing cycle and subsequently gating the PRFS MR thermometry, MR-ARFI measurement, and MRgHIFU sonication in the upper abdomen. MATERIALS AND METHODS: A digital camera was reengineered to remove its magnetic parts and was further equipped with a 7?m long USB cable. The system was electromagnetically shielded and operated inside the bore of a closed 3T clinical scanner. Suitable triggers were generated based on real-time motion analysis of the images produced by the camera (resolution 640 × 480 pixels, 30?fps). Respiratory-gated MR-ARFI prepared MRgHIFU ablation was performed in the kidney and liver of two sheep in vivo, under general anaesthesia and ventilator-driven forced breathing. RESULTS: The optical device demonstrated very good MR compatibility. The current setup permitted the acquisition of motion artefact-free and high resolution MR 2D ARFI and multiplanar interleaved PRFS thermometry (average SNR 30 in liver and 56 in kidney). Microscopic histology indicated precise focal lesions with sharply delineated margins following the respiratory-gated HIFU sonications. CONCLUSION: The proof-of-concept for respiratory motion management in MRgHIFU using an in-bore digital camera has been validated in vivo.

SUBMITTER: Auboiroux V 

PROVIDER: S-EPMC3925565 | BioStudies | 2014-01-01

REPOSITORIES: biostudies

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