Unknown

Dataset Information

0

Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors.


ABSTRACT: A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 ?M to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be a potent slow tight binding inhibitor (IC50=0.5 nM) with a strong binding to sEH (Ki=3.1 nM) and a moderately long residence time on the enzyme (koff=1.05 × 10(-3) s(-1); t1/2=11 min).

SUBMITTER: Burmistrov V 

PROVIDER: S-EPMC4019751 | BioStudies | 2014-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6442743 | BioStudies
2006-01-01 | S-EPMC1904344 | BioStudies
2015-01-01 | S-EPMC4654407 | BioStudies
2015-01-01 | S-EPMC4656071 | BioStudies
2009-01-01 | S-EPMC2888647 | BioStudies
2015-01-01 | S-EPMC4319826 | BioStudies
2007-01-01 | S-EPMC2596069 | BioStudies
2017-01-01 | S-EPMC5417501 | BioStudies
2010-01-01 | S-EPMC3070159 | BioStudies
2013-01-01 | S-EPMC3541548 | BioStudies