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Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response.


ABSTRACT: In a search for retinoid X receptor-like molecules in Drosophila, we have identified an additional member of the nuclear receptor superfamily, XR78E/F. In the DNA-binding domain, XR78E/F is closely related to the mammalian receptor TR2, as well as to the nuclear receptors Coup-TF and Seven-up. We demonstrate that XR78E/F binds as a homodimer to direct repeats of the sequence AGGTCA. In transient transfection assays, XR78E/F represses ecdysone signaling in a DNA-binding-dependent fashion. XR78E/F has its highest expression in third-instar larvae and prepupae. These experiments suggest that XR78E/F may play a regulatory role in the transcriptional cascade triggered by the hormone ecdysone in Drosophila.

SUBMITTER: Zelhof AC 

PROVIDER: S-EPMC40634 | BioStudies | 1995-01-01T00:00:00Z

SECONDARY ACCESSION(S): U31517

REPOSITORIES: biostudies

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