Dataset Information


Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.

ABSTRACT: The aim of this study was to establish reference intervals in healthy children for two novel urinary biomarkers of acute kidney injury, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL).Urinary biomarkers were determined in samples from children in the UK (n = 120) and the USA (n = 171) using both Meso Scale Discovery (MSD) and Luminex-based analytical approaches.95% reference intervals for each biomarker in each cohort are presented and stratified by sex or ethnicity where necessary, and age-related variability is explored using quantile regression. We identified consistently higher NGAL concentrations in females than males (p < 0.0001), and lower KIM-1 concentrations in African-Americans than Caucasians (p = 0.02). KIM-1 demonstrated diurnal variation, with higher concentrations in the morning (p < 0.001).This is the first report of reference intervals for KIM-1 and NGAL using two analytical methods in a healthy pediatric population in both UK and US-based populations.


PROVIDER: S-EPMC4076175 | BioStudies | 2014-01-01

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC5028052 | BioStudies
2017-01-01 | S-EPMC5395225 | BioStudies
2020-01-01 | S-EPMC7575457 | BioStudies
2017-01-01 | S-EPMC5738030 | BioStudies
2016-01-01 | S-EPMC6806694 | BioStudies
2021-01-01 | S-EPMC7863046 | BioStudies
1000-01-01 | S-EPMC4633784 | BioStudies
2019-01-01 | S-EPMC6656531 | BioStudies
1000-01-01 | S-EPMC3064060 | BioStudies
2013-01-01 | S-EPMC3825509 | BioStudies