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Tumor necrosis factor-? gene polymorphisms in Korean patients with recurrent spontaneous abortion.


ABSTRACT: The objective of this study was to investigate the contribution of the tumor necrosis factor-? (TNF-?) gene polymorphisms to recurrent spontaneous abortion (RSA). The study participants consisted of 357 Korean women with RSA and 236 fertile women controls. Four TNF-? gene variants of all participants were analyzed by polymerase chain reaction-restriction fragment length polymorphism assay. The TNF-? -1031T>C and TNF-? -238G>A variants increased the risk of RSA TNF-? -1031TC+CC; adjusted odds ratio [AOR], 2.292; 95% confidence interval [CI], 1.547-3.395; P < .001; TNF-? -238GA+AA; AOR, 2.327; 95% CI, 1.038-5.217; P = .040), and these data were not different in a stratified analysis according to the number of consecutive spontaneous abortions. Also, the mutant genotypes of TNF-? -1031 and TNF-? -238 showed synergistic effects on increased RSA risk (-1031TC+CC/-238GA+AA; AOR, 4.054; 95% CI, 1.520-10.812; P = .005). In haplotype analysis, there were similar trends of data for combination analysis. In conclusion, the TNF-? -1031T>C and TNF-? -238G>A variants are possible genetic risk factors for RSA.

SUBMITTER: Lee BE 

PROVIDER: S-EPMC4077515 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

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