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N-[(1-Benzoyl-piperidin-4-yl)meth-yl]benzamide.

ABSTRACT: In the title compound, C20H22N2O2, the piperidine ring adopts a chair conformation. The phenyl rings are inclined to one another by 80.1?(1)° and make dihedral angles of 46.1?(1) and 40.2?(1)° with the mean plane of the piperidine ring. In the crystal, pairs of N-H?O hydrogen bonds link the mol-ecules into inversion dimers. C-H?O inter-actions further link the mol-ecules, forming a three-dimensional supramolecular network.

PROVIDER: S-EPMC4120622 | BioStudies |

REPOSITORIES: biostudies

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Crystal structure of 4-chloro-N-[2-(piperidin-1-yl)eth-yl]benzamide monohydrate.

Project description:In the title compound, C14H19ClN2O2·H2O, the piperdine ring adopts a chair conformation. The dihedral angle between the mean plane of the piperidine ring and that of the phenyl ring is 41.64?(1)°. In the crystal, mol-ecules are linked by O-H?N, N-H?O and C-H?O hydrogen bonds involving the water mol-ecule, forming double-stranded chains propagating along [010].

2015-01-01 | S-EPMC4331843 | BioStudies

Crystal structure of (4-chloro-phen-yl)(4-methyl-piperidin-1-yl)methanone.

Project description:The title compound, C13H16ClNO, contains a methyl-piperidine ring in the stable chair conformation. The mean plane of the twisted piperidine ring subtends a dihedral angle of 39.89?(7)° with that of the benzene ring. In the crystal, weak C-H?O inter-actions link the mol-ecules along the a-axis direction to form infinite mol-ecular chains. H?H inter-atomic inter-actions, C-H?O inter-molecular inter-actions and weak dispersive forces stabilize mol-ecular packing and form a supra-molecular network, as established by Hirshfeld surface analysis.

| S-EPMC7133048 | BioStudies

4-[(2-Hydr-oxy-1-naphth-yl)(piperidin-1-yl)meth-yl]benzonitrile.

Project description:In the title compound, C(23)H(22)N(2)O, obtained from the condensation reaction of 4-formyl-benzonitrile, 2-naphthol and piperidine, the dihedral angle between the naphthalene ring system and the benzene ring is 75.31?(4)°. The piperidine ring adopts a chair conformation. The crystal structure is stabilized by inter-molecular C-H?N hydrogen bonds, which link the mol-ecules into centrosymmetric dimers. An intra-molecular O-H?N hydrogen bond is also present.

2009-01-01 | S-EPMC2970085 | BioStudies

3-Hy-droxy-1-(4-meth-oxy-benz-yl)piperidin-2-one.

Project description:The title compound, C13H17NO3, adopts a conformation in which the aromatic ring and the mean plane of the piperidine ring are almost perpendicular to each other [dihedral angle = 79.25?(6)°]. The presence of the carbonyl group alters the conformation of the piperidine ring from a chair to a twisted half-chair conformation. In the crystal, pairs of strong O-H?O hydrogen bonds link the mol-ecules into inversion dimers. Weak C-H?O inter-actions extend the hydrogen-bonding network into three dimensions.

| S-EPMC3588348 | BioStudies

1-(Piperidin-1-yl)-9,10-anthraquinone.

Project description:In the title compound, C(19)H(17)NO(2), the piperidine ring adopts a chair conformation. The mean planes of the piperidine ring and the anthracene ring system are inclined at a dihedral angle of 38.7?(1)°. In the crystal, adjacent mol-ecules are linked through C-H?? and ?-? [centroid-centroid distance = 3.782?(1)?Å] inter-actions, forming a layer parallel to the bc plane.

| S-EPMC3470233 | BioStudies

(2,6-Difluoro-phen-yl)(4-methyl-piperidin-1-yl)methanone.

Project description:In the title compound, C(13)H(15)F(2)NO, the piperidine ring adopts a chair conformation. The dihedral angle between the least-squares plane of the piperidine ring and the benzene ring is 48.75?(7)°. In the crystal structure, the mol-ecules are connected via C-H?O hydrogen bonds, forming a zigzag chain along the b axis.

2011-01-01 | S-EPMC3200831 | BioStudies

N-Methacryloyl-4-(piperidin-1-yl)-1,8-naphthalimide.

Project description:In the title compound, C(21)H(20)N(2)O(3), the naphthalimide unit is almost planar (r.m.s. deviation for the 15 non-H atoms = 0.059?Å). The carboximide N atom and the five C atoms of the 2-methyl-prop-2-enoyl substituent also lie in a plane (r.m.s. deviation = 0.009?Å), which subtends an angle of 84.34?(7)° to the naphthalamide plane. This orients the =CH(2) group of the vinyl fragment towards the naphthalimide rings, giving the mol-ecule an extended configuration. The piperidine ring adopts a chair conformation and there is evidence for some delocalization between the naphthalene and piperidine units, the C-N(pip) bond length being 1.404?(4)?Å. In the crystal structure, ?-? contacts with centroid-centroid distances of 3.5351?(18) and 3.7794?(18)?Å supported by C-H?O hydrogen bonds link adjacent mol-ecules in a head-to-tail fashion, forming dimers. These are further stabilized by other C-H?O contacts of varying strength, which stack the mol-ecules down the b axis.

| S-EPMC2979536 | BioStudies

1-{[5-(4-Chloro-phen-yl)-1-(4-fluoro-phen-yl)-1H-pyrazol-3-yl]carbon-yl]}piperidin-4-one.

Project description:In the title compound, C(21)H(17)ClFN(3)O(2), the 1H-pyrazole ring makes dihedral angles of 36.73?(7), 18.73?(7) and 60.88?(8)°, respectively, with the mean planes of the chloro-phenyl, 4-oxo-piperidine and fluoro-phenyl rings. The mol-ecular structure is stabilized by an intra-molecular C-H?N hydrogen bond, which forms an S(6) ring motif. In the crystal, inter-molecular C-H?O hydrogen bonds link mol-ecules into chains along [101]. In addition, inter-molecular C-H?F hydrogen bonds with an R(2) (1)(7) ring motif connect neighbouring chains into layers parallel to the ac plane.

| S-EPMC3011612 | BioStudies

1-(2,2-Di-chloro-acet-yl)-3-ethyl-2,6-di-phenyl-piperidin-4-one.

Project description:The asymmetric unit of the title compound, C21H21Cl2NO2, contains two independent mol-ecules that show similar geometrical features. The piperidine ring adopts a distorted boat conformation. The phenyl rings substituted at the 2- and 6-positions of the piperidine ring are oriented at angles of 65.4?(1) [64.7?(2)°] and 89.2?(1)° [86.3?(2)°] with respect to the least-squares plane of the piperidine ring. In the crystal, adjacent mol-ecules are linked by a network of C-H?O inter-actions, forming a C(6) chain along the c-axis direction.

2013-01-01 | S-EPMC3648321 | BioStudies

(1-Acetyl-2,6-diphenyl-piperidin-4-yl-idene)(phen-yl)acetonitrile.

Project description:In the title mol-ecule, C(27)H(24)N(2)O, the piperidine ring adopts a boat conformation. The acetyl group at position 1 has a bis-ectional orientation. The two phenyl rings attached to the piperidine ring at positions 2 and 6 have bis-ectional and axial orientations, respectively, and make a dihedral angle of 75.27?(10)°. The phenyl-acetonitrile group at position 4 has an equatorial orientation. Mol-ecules are linked by C-H?N, C-H?O inter-molecular and C-H?? inter-actions. A C-H?O intra-molecular inter-action is also found in the mol-ecule.

2008-01-01 | S-EPMC2961162 | BioStudies

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