Dataset Information


LTB4 is a signal-relay molecule during neutrophil chemotaxis.

ABSTRACT: Neutrophil recruitment to inflammation sites purportedly depends on sequential waves of chemoattractants. Current models propose that leukotriene B(4) (LTB(4)), a secondary chemoattractant secreted by neutrophils in response to primary chemoattractants such as formyl peptides, is important in initiating the inflammation process. In this study we demonstrate that LTB(4) plays a central role in neutrophil activation and migration to formyl peptides. We show that LTB(4) production dramatically amplifies formyl peptide-mediated neutrophil polarization and chemotaxis by regulating specific signaling pathways acting upstream of actin polymerization and MyoII phosphorylation. Importantly, by analyzing the migration of neutrophils isolated from wild-type mice and mice lacking the formyl peptide receptor 1, we demonstrate that LTB(4) acts as a signal to relay information from cell to cell over long distances. Together, our findings imply that LTB(4) is a signal-relay molecule that exquisitely regulates neutrophil chemotaxis to formyl peptides, which are produced at the core of inflammation sites.


PROVIDER: S-EPMC4141281 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3575564 | BioStudies
2014-01-01 | S-EPMC3897492 | BioStudies
2010-01-01 | S-EPMC3071587 | BioStudies
2008-01-01 | S-EPMC2568933 | BioStudies
2018-01-01 | S-EPMC6176921 | BioStudies
2006-01-01 | S-EPMC1895409 | BioStudies
1000-01-01 | S-EPMC3423786 | BioStudies
1000-01-01 | S-EPMC4478797 | BioStudies
2019-01-01 | S-EPMC6744913 | BioStudies
2010-01-01 | S-EPMC2858774 | BioStudies