Unknown

Dataset Information

0

Comparison of patient reported quality of life and impact of treatment side effects experienced with a taxane-containing regimen and standard anthracycline based chemotherapy for early breast cancer: 6 year results from the UK TACT trial (CRUK/01/001).


ABSTRACT:

Background

The TACT trial (CRUK/01/001) compared adjuvant sequential FEC-docetaxel (FEC-D) chemotherapy with standard anthracycline-based chemotherapy of similar duration in women with early breast cancer. Results at a median of 5 years suggested no improvement in disease-free survival with FEC-D. Given differing toxicity profiles of the regimens, the impact on quality of life (QL) was explored.

Methods

Patients from 44 centres completed standardised QL questionnaires before chemotherapy, after cycles 4 and 8, at 9, 12, 18 and 24 months and at 6 years follow-up. Patient diaries assessed frequency, associated distress and impact on daily activity of 15 treatment related side effects.

Findings

830 patients (415 FEC-D; 415 controls) contributed assessments during 0-24 months; 362 of whom participated again at 6 years. During chemotherapy, FEC-D impaired global health/QL and depression rates and significantly more QL domains than standard regimens. Novel diary card ratings highlighted significantly more distress and interference with daily activities due to FEC-D side effects compared with standard treatment. In both groups, most QL parameters returned to baseline levels by 2 years and were unchanged at 6 years.

Interpretation

Within expected negative effects of chemotherapy on wide ranging QL domains FEC-D patients reported greater toxicity, disruption and distress during treatment with no improvement in disease outcome at 5 years than patients receiving standard anthracycline-based chemotherapy. Findings should inform future patients of relative costs and benefits of adjuvant chemotherapy.

SUBMITTER: Hall E 

PROVIDER: S-EPMC4166460 | BioStudies | 2014-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7103001 | BioStudies
2019-01-01 | S-EPMC6640206 | BioStudies
2005-01-01 | S-EPMC548292 | BioStudies
2011-01-01 | S-EPMC4172919 | BioStudies
2008-01-01 | S-EPMC5527786 | BioStudies
2020-01-01 | S-EPMC7253732 | BioStudies
2020-01-01 | S-EPMC7583247 | BioStudies
2013-01-01 | S-EPMC3608881 | BioStudies
1000-01-01 | S-EPMC3858998 | BioStudies
2009-01-01 | S-EPMC2679760 | BioStudies