Dataset Information


Efficient bioconversion of 2,3-butanediol into acetoin using Gluconobacter oxydans DSM 2003.



2,3-Butanediol is a platform and fuel biochemical that can be efficiently produced from biomass. However, a value-added process for this chemical has not yet been developed. To expand the utilization of 2,3-butanediol produced from biomass, an improved derivative process of 2,3-butanediol is desirable.


In this study, a Gluconobacter oxydans strain DSM 2003 was found to have the ability to transform 2,3-butanediol into acetoin, a high value feedstock that can be widely used in dairy and cosmetic products, and chemical synthesis. All three stereoisomers, meso-2,3-butanediol, (2R,3R)-2,3-butanediol, and (2S,3S)-2,3-butanediol, could be transformed into acetoin by the strain. After optimization of the bioconversion conditions, the optimum growth temperature for acetoin production by strain DSM 2003 was found to be 30°C and the medium pH was 6.0. With an initial 2,3-butanediol concentration of 40 g/L, acetoin at a high concentration of 89.2 g/L was obtained from 2,3-butanediol by fed-batch bioconversion with a high productivity (1.24 g/L?·?h) and high yield (0.912 mol/mol).


G. oxydans DSM 2003 is the first strain that can be used in the direct production of acetoin from 2,3-butanediol. The product concentration and yield of the novel process are both new records for acetoin production. The results demonstrate that the method developed in this study could provide a promising process for efficient acetoin production and industrially produced 2,3-butanediol utilization.


PROVIDER: S-EPMC4177140 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3788785 | BioStudies
2021-01-01 | S-EPMC7816431 | BioStudies
2011-01-01 | S-EPMC3126369 | BioStudies
2010-01-01 | S-EPMC2811184 | BioStudies
2014-01-01 | S-EPMC3909405 | BioStudies
2018-01-01 | S-EPMC6017632 | BioStudies
1000-01-01 | S-EPMC6267845 | BioStudies
2013-01-01 | S-EPMC3563507 | BioStudies
2016-01-01 | S-EPMC4899745 | BioStudies
2008-01-01 | S-EPMC2583490 | BioStudies