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Viral sequence analysis of HIV-positive women and their infected children: insight on the timing of infection and on the transmission network.


ABSTRACT: We used high-resolution phylogenetic methods in the context of mother-to-child transmission to obtain information on the timing of the infection and on the transmission network. A total of 33 pol sequences (from maternal peripheral blood, from breast milk, and from plasma of children) belonging to five cases of HIV infant transmission were studied. Using time-scaled phylogeny we were able to estimate that in two cases the transmission occurred after the recommended duration of breastfeeding, supporting a longer, not reported, duration of breastfeeding as a significant factor associated with HIV infant acquisition in this cohort. Among the postnatal infections we were also able to demonstrate that the cell-free virus in breast milk was the most likely population associated with the event of transmission. Our study showed that a coalescent-based model within a Bayesian statistical framework can provide important information that can contribute to optimizing preventive strategies.

SUBMITTER: Ciccozzi M 

PROVIDER: S-EPMC4179918 | BioStudies | 2014-01-01

SECONDARY ACCESSION(S): KM233418

REPOSITORIES: biostudies

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