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Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes.


ABSTRACT: A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1?, GT1a?, and GQ1b? is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic ?2-6-sialylation. This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives.

SUBMITTER: Meng X 

PROVIDER: S-EPMC4210053 | BioStudies | 2014-01-01T00:00:00Z

REPOSITORIES: biostudies

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