Unknown

Dataset Information

0

Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.


ABSTRACT: The goal of our study was to explore the significant association between a non-protein coding single nucleotide polymorphism (SNP) rs4977574 of CDKN2BAS gene and coronary heart disease (CHD). A total of 590 CHD cases and 482 non-CHD controls were involved in the present association study. A strong association of rs4977574 with CHD was observed in females (genotype: p=0.002; allele: p=0.002, odd ratio (OR)=1.57, 95% confidential interval (CI)=1.18-2.08). Moreover, rs4977574 was more likely to be a risk variant of CHD under the recessive model in females (?2=10.29, p=0.003, OR=2.14, 95% CI=1.31-2.77). A breakdown analysis by age had shown that there was an 87% increased risk of CHD for females younger than 65 years (genotype: ?2=14.64, degrees of freedom (df)=2, p=0.0002; allele: ?2=11.31, df=1, p=0.0008, OR=1.87, 95% CI=1.30-2.70). Similar observation was also found in males younger than 65 years (genotype: ?2=8.63, df=2, p=0.04; allele: ?2=7.55, df=1, p=0.006, OR=1.45, 95% CI=1.11-1.90). p values were adjusted by age, sex, smoking, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Meta-analysis of 23 studies among 36,452 cases and 39,781 controls showed a strong association between rs4977574 and the risk of CHD (p<0.0001, OR=1.27, 95% CI=1.22-1.31).

SUBMITTER: Huang Y 

PROVIDER: S-EPMC4227174 | BioStudies | 2014-01-01

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3903165 | BioStudies
2018-01-01 | S-EPMC5998860 | BioStudies
2020-01-01 | S-EPMC7026955 | BioStudies
2015-01-01 | S-EPMC4550406 | BioStudies
2018-01-01 | S-EPMC5864789 | BioStudies
2016-01-01 | S-EPMC4849041 | BioStudies
2020-01-01 | S-EPMC7440310 | BioStudies
2008-01-01 | S-EPMC2507759 | BioStudies
2018-01-01 | S-EPMC6181537 | BioStudies
2014-01-01 | S-EPMC3899088 | BioStudies