Unknown

Dataset Information

0

A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaques.


ABSTRACT: Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons tested were SHFV positive and the infections persisted for more than 10 years with detectable virus in the blood (100-1000 genomes/ml). The sequences of two baboon SHFV isolates that were amplified by a single passage in primary macaque macrophages had a high degree of identity to each other as well as to the genome of SHFV-LVR, a laboratory strain isolated in the 1960s. Infection of Japanese macaques with 100PFU of a baboon isolate consistently produced high level viremia, pro-inflammatory cytokines, elevated tissue factor levels and clinical signs indicating coagulation defects. The baboon virus isolate provides a reliable BSL2 model of viral hemorrhagic fever disease in macaques.

SUBMITTER: Vatter HA 

PROVIDER: S-EPMC4304765 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

2015-01-01 | S-EPMC4449332 | BioStudies
2014-01-01 | S-EPMC3911543 | BioStudies
2014-01-01 | S-EPMC4249091 | BioStudies
2016-01-01 | S-EPMC4791849 | BioStudies
2015-01-01 | S-EPMC4505640 | BioStudies
2013-01-01 | S-EPMC3536393 | BioStudies
2014-01-01 | S-EPMC3961216 | BioStudies
2019-01-01 | S-EPMC6356329 | BioStudies
1000-01-01 | S-EPMC188954 | BioStudies
2014-01-01 | S-EPMC4192379 | BioStudies