Unknown

Dataset Information

0

Bone-targeted therapy in metastatic breast cancer - all well-established knowledge?


ABSTRACT: Bone-targeted therapies like bisphosphonates (zoledronic acid or pamidronate) or denosumab are recommended in all patients with metastatic breast cancer and bone metastases, whether they are symptomatic or not. The choice between these 2 different agents, however, remains open. In this review, we critically discuss the emerging evidence for direct anti-tumor activity of bone-targeting agents, the utility of bone turnover markers for treatment decision and efficacy prediction, as well as the safety and financial aspects of bisphosphonates and denosumab. Furthermore, we provide a possible therapeutic algorithm, and present new pharmacologic agents which are being investigated for the treatment of metastatic bone disease.

SUBMITTER: Gampenrieder SP 

PROVIDER: S-EPMC4322685 | BioStudies | 2014-01-01

SECONDARY ACCESSION(S): NCT00691899

REPOSITORIES: biostudies

Similar Datasets

2016-01-01 | S-EPMC4807885 | BioStudies
2011-01-01 | S-EPMC3169928 | BioStudies
1000-01-01 | S-EPMC3227909 | BioStudies
2013-01-01 | S-EPMC3771418 | BioStudies
2019-01-01 | S-EPMC6751527 | BioStudies
2014-01-01 | S-EPMC4023357 | BioStudies
2018-01-01 | S-EPMC5919994 | BioStudies
1000-01-01 | S-EPMC5440603 | BioStudies
2015-01-01 | S-EPMC4399231 | BioStudies
1000-01-01 | S-EPMC2769231 | BioStudies