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Comparison of antiviral activity of lambda-interferons against HIV replication in macrophages.


ABSTRACT: Lambda-interferons (IFN-?s) have been demonstrated as having the ability to inhibit HIV replication in macrophages. However, specific differences in signaling transduction and anti-HIV activity in macrophages between different IFN-?s are unclear. Here, we showed that although all 3 members of (IFN-?1, ?2, and ?3) IFN-? family induced the expression of a number of genes of janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway in monocyte-derived macrophages, IFN-?1 or IFN-?3 induced higher levels of antiviral IFN-stimulated genes (ISGs) expression than did IFN-?2. In addition, IFN-?1 or IFN-?3 induced higher levels of several pattern recognition receptors (PPRs) than did IFN-?2. Incubation of IFN-?s with HIV-infected macrophages showed that IFN-?1 or IFN-?3 is more potent in anti-HIV activity than IFN-?2. We also showed that IFN-? treatment before HIV infection was more potent in HIV inhibition than that after HIV infection. Further investigations showed that the inductions of ISGs and PPRs expression by IFN-?s were largely compromised by HIV infection. These findings provide further experimental evidence that IFN-?s have therapeutic potential in treatment of HIV infection.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4350265 | BioStudies | 2015-01-01T00:00:00Z

REPOSITORIES: biostudies

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