Dataset Information


Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population.

ABSTRACT: OBJECTIVE:To investigate genetic and lifestyle factors and their interactions on plasma homocysteine (Hcy) concentrations in the Boston Puerto Rican population. DESIGN:Cross-sectional study. Plasma concentrations of Hcy, folate, vitamin B12 and pyridoxal phosphate were measured, and genetic polymorphisms were determined. Data on lifestyle factors were collected in interviews. SETTING:A population survey of health and nutritional measures. SUBJECTS:A total of 994 Puerto Rican men and women residing in the Boston metropolitan area. RESULTS:Smoking status was positively associated with plasma Hcy. Genetic polymorphisms MTHFR 677C?T, FOLH1 1561C?T, FOLH1 rs647370 and PCFT 928A?G interacted significantly with smoking for Hcy. MTHFR 1298A?C (P = 0·040) and PCFT 928A?G (P = 0·002) displayed significant interactions with alcohol intake in determining plasma Hcy. Subjects with PCFT 928GG genotype had significantly higher plasma Hcy concentrations compared with carriers of the A allele (AA+AG; P = 0·030) among non-drinking subjects. When consuming alcohol, GG subjects had lower plasma Hcy levels compared with AA+AG subjects. Physical activity interacted significantly with MTR 2756A?G in determining plasma Hcy (P for interaction = 0·002). Smoking interacted with physical activity for plasma Hcy (P for interaction = 0·023). CONCLUSIONS:Smoking and drinking were associated plasma Hcy concentrations. Genetic variants involved in folate metabolism further modify the effects of lifestyle on plasma Hcy.


PROVIDER: S-EPMC4357314 | BioStudies | 2011-01-01

REPOSITORIES: biostudies

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