Unknown

Dataset Information

0

Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents.


ABSTRACT: A series of structurally diverse 4-bromo spiro-isoxazolines possessing a variety of aromatic and aliphatic substituents at the 3 position, were synthesized through a 1,3-dipolar cycloaddition followed by intramolecular cyclization of a pendant hydroxyl or carboxylic acid group. The biochemical antiproliferative activity was evaluated in vitro by using two breast cancer cell lines (MCF-7 and MDA-MB-231) and two prostate cancer cell lines (PC-3 and DU-145) using the MTT viability assay, and the IC50 values were obtained. Spiro-isoxazoline derivatives bearing a p-chloro or an o-dichloro aromatic substituent at the 3-position of the isoxazoline showed considerable antitumor activities in all four cell lines with IC50 value ranging from 43?M to 56?M.

PROVIDER: S-EPMC4371604 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

2008-01-01 | S-EPMC2960307 | BioStudies
1000-01-01 | S-EPMC3869255 | BioStudies
1000-01-01 | S-EPMC3588835 | BioStudies
1000-01-01 | S-EPMC6271256 | BioStudies
1000-01-01 | S-EPMC3008056 | BioStudies
| S-EPMC3376396 | BioStudies
2021-01-01 | S-EPMC7910433 | BioStudies
| S-EPMC7179167 | BioStudies
| S-EPMC6641983 | BioStudies
2017-01-01 | S-EPMC6044920 | BioStudies