Unknown

Dataset Information

0

Serum biomarkers in patients with relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss).


ABSTRACT: Previous studies suggest a role for eotaxin-3, TARC/CCL17 and IgG4 in newly-diagnosed patients with eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss) with highly active disease. The role of these biomarkers in relapsing disease is unclear.Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio were determined in serum samples from a longitudinal cohort of patients with EGPA (105 visits of 25 patients). Epidemiological, clinical and laboratory data were available for all visits.At the first visit, 80% of patients were using glucocorticoids and 68% additional immunosuppressive drugs. Disease flares were seen at 18 visits. The median BVAS and BVAS/WG scores at time of relapse were 4 and 2, respectively. None of the biomarkers tested were useful to discriminate between active disease and remission. Patients treated with prednisone had lower eotaxin-3 and eosinophil levels compared to patients not taking glucocorticoids irrespective of disease activity. Use of immunosuppressive agents was not associated with biomarker levels.Serum levels of TARC/CCL17, eotaxin-3, IgG4, and IgG4/IgG ratio do not clearly differentiate active and inactive disease in established EGPA. Defining biomarkers in EGPA remains a challenge especially during times of glucocorticoid use.

SUBMITTER: Dejaco C 

PROVIDER: S-EPMC4374913 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7355369 | BioStudies
2018-01-01 | S-EPMC6110302 | BioStudies
2018-01-01 | S-EPMC6181402 | BioStudies
2017-01-01 | S-EPMC5655820 | BioStudies
1000-01-01 | S-EPMC4476489 | BioStudies
2019-01-01 | S-EPMC6357433 | BioStudies
2015-01-01 | S-EPMC4560122 | BioStudies
2017-01-01 | S-EPMC5592199 | BioStudies
1000-01-01 | S-EPMC5889992 | BioStudies
1000-01-01 | S-EPMC6332970 | BioStudies