Dataset Information


Association of THBS1 rs1478605 T>C in 5'-untranslated regions with the development and progression of gastric cancer.

ABSTRACT: Thrombospondin 1 (THBS1) plays an important role in angiogenesis and tumor progression. The aim of the present study was to investigate the effects of single-nucleotide polymorphisms (rs1478605 and rs3743125) in the untranslated regions of the THBS1 gene on the development and progression of gastric cancer. In the case-control study, 275 gastric cancer patients and 275 cancer-free controls were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism. The data demonstrated that THBS1 rs1478605 genotypic distributions significantly differed between the patient and control groups (P=0.005). Carriers of the CC genotype exhibited a decreased risk of developing gastric cancer compared to the carriers of the CT and TT genotypes [adjusted odd ratio (OR), 0.56; 95% confidence interval (CI), 0.39-0.79; P=0.001]. The CC genotype of rs1478605 was negatively associated with gastric cancer lymph node metastasis (OR, 0.41; 95% CI, 0.23-0.71; P=0.001) and was associated with a reduced risk of lymph node metastasis in male patients (OR, 0.27; 95% CI, 0.14-0.52; P<0.001). The THBS1 CT haplotype was associated with a reduced risk of developing gastric cancer (OR, 0.56; 95% CI, 0.33-0.93; P=0.02). By contrast, no association was observed between THBS1 rs3743125 and the development and progression of gastric cancer. These results suggest that THBS1 rs1478605 represents a potential molecular marker for gastric cancer.


PROVIDER: S-EPMC4448071 | BioStudies | 2015-01-01


REPOSITORIES: biostudies

Similar Datasets

2015-01-01 | S-EPMC4589757 | BioStudies
2019-01-01 | S-EPMC6722488 | BioStudies
2020-01-01 | S-EPMC7647771 | BioStudies
2014-01-01 | S-EPMC4197802 | BioStudies
2011-01-01 | S-EPMC3410591 | BioStudies
2015-01-01 | S-EPMC4506573 | BioStudies
2019-01-01 | S-EPMC6893172 | BioStudies
2017-01-01 | S-EPMC6965378 | BioStudies
2016-01-01 | S-EPMC4844435 | BioStudies
2018-01-01 | S-EPMC6245525 | BioStudies