Unknown

Dataset Information

0

Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide.


ABSTRACT: A biotinylated heparosan hexasaccharide was synthesized using a one-pot multi-enzyme strategy, in situ activation and transfer of N-trifluoroacetylglucosamine (GlcNTFA) to a heparin backbone significantly improved the synthetic efficiency. The biotinylated hexasaccharide could serve as a flexible core to diversify its conversion into heparan sulfate isoforms with potential biological applications and therapeutics.

PROVIDER: S-EPMC4472006 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6691538 | BioStudies
2010-01-01 | S-EPMC2811250 | BioStudies
| S-EPMC3390146 | BioStudies
| S-EPMC3153860 | BioStudies
1000-01-01 | S-EPMC3998769 | BioStudies
1000-01-01 | S-EPMC4070978 | BioStudies
1000-01-01 | S-EPMC3230279 | BioStudies
2012-01-01 | S-EPMC3418500 | BioStudies
| S-EPMC2974770 | BioStudies
2020-01-01 | S-EPMC7694667 | BioStudies