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Total Synthesis of (-)-Nodulisporic Acid D.


ABSTRACT: A convergent total synthesis of the architecturally complex indole diterpenoid (-)-nodulisporic acid D has been achieved. Key synthetic transformations include vicinal difunctionalization of an advanced ?,?-unsaturated aldehyde to form the E,F-trans-fused 5,6-ring system of the eastern hemisphere and a cascade cross-coupling/indolization protocol leading to the CDE multisubstituted indole core.

SUBMITTER: Zou Y 

PROVIDER: S-EPMC4479160 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

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