Unknown

Dataset Information

0

Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.


ABSTRACT: DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5-Smc6 complex is recruited to DSBs de novo to support their repair by homologous recombination between sister chromatids. In addition, we demonstrate that Smc5-Smc6 is necessary to suppress gross chromosomal rearrangements. Our findings show that the Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events.

PROVIDER: S-EPMC4493748 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC3820751 | BioStudies
2004-01-01 | S-EPMC522231 | BioStudies
2011-01-01 | S-EPMC3120815 | BioStudies
2008-01-01 | S-EPMC2555936 | BioStudies
2015-01-01 | S-EPMC4434891 | BioStudies
2004-01-01 | S-EPMC343814 | BioStudies
1000-01-01 | S-EPMC1523187 | BioStudies
2019-01-01 | S-EPMC6511331 | BioStudies
2011-01-01 | S-EPMC3102082 | BioStudies
2013-01-01 | S-EPMC3610895 | BioStudies