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Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.


ABSTRACT: Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.

SUBMITTER: van de Sandt CE 

PROVIDER: S-EPMC4542594 | BioStudies | 2015-01-01T00:00:00Z

REPOSITORIES: biostudies

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